Evidence map›Paper›PMID 41186277›Full record

ArticleChemical research in toxicology2025

RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength.

Justin C Dingman, Aaron M Fleming, Cynthia J Burrows

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Justin C DingmanDepartment of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, Utah 84112-0850, United States.
Aaron M FlemingDepartment of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, Utah 84112-0850, United States.ORCID 0000-0002-2000-0310
Cynthia J BurrowsDepartment of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, Utah 84112-0850, United States.ORCID 0000-0001-7253-8529

Funding

Chemical Modifications in Regulatory Regions of DNA and RNAR35GM145237 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Cynthia J Burrows · 2022 to 2026
$2.3M
NIGMS NIH HHS R35 GM145237
6 · The paper itself

Abstract

Oxidative damage to RNA is associated with neurodegeneration, cardiovascular diseases, and cancer development. Studies that monitor RNA damage by H

Indexed as

BicarbonatesLigandsOxidative StressEscherichia coliHEK293 CellsHumansHydrogen PeroxideIronOxidation-ReductionPhthalic AcidsRNABicarbonatesFenton's reagentHydrogen PeroxideIronLigandsPhthalic AcidsRNAterephthalic acid

Identifiers

PMID41186277
PMCPMC12628338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.