Evidence map›Paper›PMID 41186215›Full record

ArticleClinical transplantation2025

Early Liver Transplantation for Alcohol-Related Liver Disease and Desire to Donate: A Nationally Representative US Survey.

Janetta Brundage, Baimaji, Mayan Teles, Rivka Abedon, Aura Teles, Hannah C Sung, Po-Hung Chen, Daniel Warren, Andrew Cameron, Olivia S Kates

Abstract read
In one paragraph

Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janetta BrundageDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
BaimajiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mayan TelesDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rivka AbedonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Aura TelesDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hannah C SungDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-4531-2094
Po-Hung ChenDivision of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel WarrenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Olivia S KatesDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Project 4-Early Liver Transplantation for Severe Alcoholic Hepatitis: Animal StudiesP50AA027054 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI ROBERT A. ANDERS · 2019 to 2026
$15.1M
Candidate Selection for Liver Transplantation in Patients with Alcohol-related Liver DiseaseK23AA028297 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI CHEN, PO-HUNG (VICTOR) · 2020 to 2024
$991k
Gilead Sciences Research Scholars Program in Liver Disease-The AmericasNational Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health K23AA028297National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health P50AA027054NIAAA NIH HHS K23 AA028297NIAAA NIH HHS P50 AA027054
6 · The paper itself

Abstract

backgroundEarly liver transplantation (ELT) describes liver transplantation (LT) for alcohol-related liver disease (ALD) performed before 6 months of alcohol abstinence, commonly known as the "6-month rule." Although recent evidence demonstrates favorable outcomes after ELT, concern that the public may withdraw from organ donation if ELT grows as a practice is underexplored empirically. We sought to investigate desire to donate after exposure to information about ELT.

methodsWe designed a public perception survey using expert feedback, cognitive interviewing, and pilot testing. We used quota-based sampling based on US national demographics and distributed the survey from November 15, 2023 to January 10, 2024 using Qualtrics research services.

resultsOf 2032 respondents who completed the survey, 57.4% of respondents reported being registered organ donors or specifying an intent to donate in a living will. After learning about ELT, 61.0% of respondents expressed agreement with ELT, a similar proportion to those who expressed agreement with LT for ALD without being given prior information (64.1%). In response to information that some centers do not require the 6-month alcohol-free period, 55.7% of respondents indicated they wanted to be an organ donor, 15.5% did not want to be a donor, and 28.8% were unsure. Of the respondents who stated they were organ donors, 82.9% reported a desire to be organ donors after exposure to information about ELT.

conclusionPublic perceptions of ELT do not appear substantially different from perceptions regarding LT for ALD. Our findings do not support concerns about widespread public withdrawal from organ donation due to ELT.

Indexed as

Liver Diseases, AlcoholicLiver TransplantationMotivationTissue and Organ ProcurementTissue DonorsAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisSurveys and QuestionnairesUnited StatesYoung Adultalcohol‐related liver diseaseearly liver transplantationethicspublic perceptionpublic survey

Identifiers

PMID41186215
PMCPMC13003384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.