Evidence map›Paper›PMID 41186020›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Near-Infrared Switch-Driven Macrophage Dynamically Reprogramming for Anti-Infection and Tissue Healing on Polyetheretherketone Implants.

Yinghao Wu, Shuaiqi Jiang, Jibing He, Ji Tan, Junjie Zhou, Zhipeng Zou, Jiaxing Wang, Jia Jiang, Xuanyong Liu, Xiaochun Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinghao WuShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Shuaiqi JiangState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Jibing HeShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Ji TanState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Junjie ZhouState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Zhipeng ZouShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Jiaxing WangShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Jia JiangShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Xuanyong LiuState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Xiaochun PengShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.ORCID https://orcid.org/0009-0003-9607-496X

Funding

Excellent Youth Training Program of Shanghai Sixth People's Hospital ynyq202202National Natural Science Foundation of China 82272570National Natural Science Foundation of China 82472461National Natural Science Foundation of China U21A20100"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2024C03080
6 · The paper itself

Abstract

High infection risk and poor tissue integration are major causes of percutaneous implant failure. Immune reprogramming is a promising strategy, but current implants rely predominantly on passive and static modulation of macrophages. Dynamically reprogramming macrophages based on physiological states to switch between antibacterial and tissue-healing functions remains a challenge. Here, a novel polyetheretherketone (PEEK) surface is developed sequentially modified through sulfonation, hydrogen plasma immersion ion implantation (H-PIII), and magnesium plasma immersion ion implantation (Mg-PIII) to fabricate a Mg-H-SPEEK composite with a graphene-like matrix embedded with MgO. This film simultaneously enables sustained Mg

Indexed as

KetonesMacrophagesPolyethylene GlycolsWound HealingAnimalsBenzophenonesInfrared RaysMicePolymersProstheses and ImplantsBenzophenonesKetonespolyetheretherketonePolyethylene GlycolsPolymersantibacteriadynamic regulationimmune reprogrammingNIR responsivetissue integration

Identifiers

PMID41186020
PMCPMC12713068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.