ArticleJournal of biophotonics2026
Fast Mid-Infrared Spectral Probe Decisions Match H&E Stain Results for Keratinocytic Carcinoma.
Article in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Fast Mid-Infrared Spectral Probe Decisions Match H&E Stain Results for Keratinocytic Carcinoma.Journal of biophotonics · 2026Article
- IR Spectroscopy and Linear Support Vector Machine Analysis of Colorectal Liver Metastasis.The journal of physical chemistry. B · 2026Article
- Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe.Journal of biophotonics · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We designed a handheld and fast mid-infrared fiber-optic spectral probe using a quantum cascade laser (QCL) and a reduced range of wavelengths, to see if keratinocytic carcinoma (KC) could be distinguished from adjacent nonmalignant tissue using discarded skin tissues from Mohs surgery. This study employed two adjacent frozen sections of discarded tissue: one was stained with H&E (the gold standard for skin cancer diagnosis) to identify the location of cancer by a pathologist, while the other was left unstained for mid-infrared spectral probing on and off cancer as guided by the adjacent H&E stain. A total of 346 spectra from 18 consenting patients were collected during Mohs surgery. After adding a dehumidifier, an accuracy of 95% was obtained on a case sample basis. It will be worthwhile to assess the probe's utility at the surface of live human skin (study approved by the Advarra Institutional Review Board [PRO00044823]).
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Registered trials
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