ArticleInfluenza and other respiratory viruses2025
Estimated Relative Effectiveness and Public Health Impact of Cell-Based Versus Egg-Based Influenza Vaccines During the 2022-2023 Season in the United States.
Article in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Effectiveness of live-attenuated and inactivated influenza vaccines against influenza in 2-17-y-old children, United States, 2022-2025.Human vaccines & immunotherapeutics · 2026Article
- Strain Matching of Seasonal Influenza Vaccines and Emergence of Neuraminidase Inhibitor Resistance in China from 2015 to 2025.Vaccines · 2026Article
- Estimated Relative Effectiveness and Public Health Impact of Cell-Based Versus Egg-Based Influenza Vaccines During the 2022-2023 Season in the United States.Influenza and other respiratory viruses · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundEgg adaptation can reduce the effectiveness of egg-based influenza vaccines. Previous studies have demonstrated improved effectiveness of cell versus egg-based quadrivalent influenza vaccines (QIVc and QIVe, respectively) during the 2017-2020 influenza seasons among persons aged ≥ 4 years. Here we evaluate the relative vaccine effectiveness (rVE) of QIVc versus QIVe in preventing test-confirmed influenza among persons aged 6 months to 64 years during the US 2022-2023 influenza season, along with the potential impact on influenza burden averted.
methodsA retrospective test-negative design was applied to linked electronic health records and claims data from QIVc or QIVe recipients who were tested for influenza in routine outpatient care within 7 days of an acute respiratory or febrile illness. rVE was estimated by comparing the odds of testing positive among QIVc versus QIVe recipients, adjusted using doubly robust methodology. The influenza burden additionally averted by vaccination with QIVc versus QIVe was estimated using a published model.
resultsOf 43,086 patients included, 18.6% received QIVc and 81.4% received QIVe. The rVE of QIVc versus QIVe was 7.7% (95% CI, 0.9%-13.9%). Use of QIVc instead of QIVe during the 2022-23 influenza season would have prevented an additional 636,209 symptomatic cases of influenza, 314,130 outpatient visits, and 3759 hospitalizations.
conclusionsQIVc was superior to QIVe in the prevention of test-confirmed influenza among persons aged 6 months to 64 years during the US 2022-2023 influenza season. The rVE of 7.7% would translate to a substantially reduced influenza burden if QIVc were used over QIVe.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.