ArticleCureus2025
Perioperative Blood Loss in Cementless Versus Cemented Total Knee Arthroplasty With Local Tranexamic Acid Administration.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCementless total knee arthroplasty (TKA) has historically been associated with greater perioperative blood loss than cemented TKA. Whether a standardized local-only tranexamic acid (TXA) regimen can mitigate this difference remains unclear.
objectiveTo compare perioperative blood loss between cementless and cemented TKA under a standardized local-only TXA protocol in a retrospective cohort, focusing on comparison rather than causation. Secondary outcomes included perioperative hemoglobin (Hb)/hematocrit (Hct) changes (preoperative to postoperative day (POD) 1), intraoperative and perioperative blood loss, transfusion, POD 7 D-dimer, operative time, and complications.
methodsWe retrospectively reviewed 103 consecutive unilateral primary TKAs performed at a single center (cementless, n=55; cemented, n=48) between 2013 and 2020. A standardized local TXA protocol was used in all cases (1 g periarticular before implantation and 1 g intra-articular before closure); no drains were used. Outcomes included operative time, perioperative Hb/Hct change, intraoperative blood loss, total perioperative blood loss estimated by the Gross formula, transfusion, complications, and POD 7 D-dimer. Group comparisons used t-tests with Welch's correction or Mann-Whitney U tests, and Fisher's exact tests for categorical variables.
resultsBaseline demographics were comparable between groups. Intraoperative blood loss was similar (cementless 91.4 ± 75.1 mL vs cemented 85.5 ± 111.2 mL; p=0.140), as was perioperative blood loss (154.3 ± 76.9 mL vs 132.9 ± 91.0 mL; p=0.204). No patient required transfusion. POD 7 D-dimer was higher in the cementless group (9.7±4.1 µg/mL vs 7.8±4.4 µg/mL; p=0.002), but no symptomatic venous thromboembolism occurred. Two late surgical-site infections in the cementless group resolved without revision or loosening; no wound complications occurred in either group.
conclusionsUnder a standardized local-only TXA protocol, cementless TKA achieved perioperative blood loss comparable to cemented TKA without increasing symptomatic thromboembolic events. These findings suggest the feasibility of a standardized local TXA protocol for cementless TKA. Importantly, fixation method was fully collinear with implant design (cementless: low contact stress (LCS) limited-box; cemented: posterior-stabilized (PS) open-box), and femoral box geometry can influence bleeding; therefore, results should be interpreted within this implant- and protocol-specific context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.