ArticleInternational journal of nanomedicine2025
PtPdNi Trimetallic-Doped MIL-88 Hydrogel Accelerates Healing of Bacterial-Infected Diabetic Wounds.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Treatment of bacterial-infected diabetic wounds is still challenging due to the susceptibility to bacterial infection and oxidative stress. Therefore, a novel multifunctional platform was established for accelerating the healing of bacterial-infected diabetic wounds. Methods: PtPdNi trimetallic-doped MIL-88 (PPNM) was fabricated and anchored to polyvinyl alcohol/sodium alginate (PVA/SA) matrix for constructing PPNM-containing hydrogel (PPNM-Gel). The basic properties of PPNM were characterized by TEM, SEM, XPS, FT-IR spectra, and UV-vis spectra. Adhesive, swelling, and degradation properties of PPNM-Gel were also analyzed. In vitro biocompatibility of PPNM-Gel was determined using L929 and HUVEC-SV40 cells. In vitro antimicrobial effects of PPNM-Gel were evaluated with Results: PPNM exhibited multienzyme-like activity including POD-like, OXD-like, CAT-like, SOD-like, and NAD-like activities. PPNM-Gel demonstrated excellent tissue adhesive activity, water absorption ability, biodegradability, and biocompatibility. In vitro testing, PPNM-Gel showed obvious antibacterial ability against Conclusion: PPNM-Gel significantly accelerated the healing of bacterial-infected diabetic wounds in the rat model. Therefore, PPNM-Gel showed great promise for the treatment of diseases affected by bacterial infections and high ROS levels.
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