ArticleJournal of inflammation research2025
METTL3/IGF2BP2-Mediated m6A RNA Methylation Drives Alveolar Macrophage-Dependent Neutrophil Recruitment in Cigarette Smoke-Induced COPD.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- RNA Modifications as Molecular Regulators of Alveolar Epithelial Injury and Aberrant Repair in Pulmonary Fibrosis.Biomolecules · 2026Review
- Review
- Oxidative stress-driven epigenetic reprogramming of immune cells in COPD: from epitranscriptomic and metabolic crosstalk to treatable traits.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Chronic inflammatory infiltration caused by cigarette smoke is one of the primary characteristics that define chronic obstructive pulmonary disease (COPD), but the epigenetic mechanisms governing immune cell crosstalk remain poorly defined. This study aims to elucidate the critical role of m Methods: A mouse COPD model was employed, combined with mechanistic studies that included pharmacological inhibition, RNA stability assay, RIP, m6A-qPCR, and cell chemotaxis assay in cells, to investigate the effect of cigarette smoke exposure on m Results: Cigarette smoke exposure upregulated METTL3 and IGF2BP2 expression in alveolar macrophages. METTL3-mediated m Discussion: Our results uncover a novel epitranscriptional pathway through which cigarette smoke promotes neutrophilic inflammation via m
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