ArticleAnnals of medicine2025
The predictive implications for stroke-associated infection and prognostic outcome of neutrophil to albumin ratio in Chinese patients with spontaneous intracerebral hemorrhage.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.Annals of medicine · 2026Article
- Development Timelines of Innovative Drugs in China: A 15-Year Cross-Sectional Analysis of Characteristics and Influencing Factors.Clinical and translational science · 2026Article
- Article
- Risk factors and development of a prediction model for hematoma expansion in elderly patients with spontaneous intracerebral hemorrhage.Frontiers in aging neuroscience · 2026Article
- Machine learning model for unfavorable outcome prediction in neurosurgical patients: the potential role of liver function markers.Frontiers in neurologyArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Neutrophil to Albumin Ratio (NAR) stands out as a novel integrative inflammatory biomarker that is associated with the occurrence of stroke-associated infection (SAI). Our objective is to comprehensively investigate the predictive capacity of NAR regarding the incidence of SAI and poor functional outcomes after spontaneous intracerebral hemorrhage (sICH).
methodsWe retrospectively enrolled 291 patients categorized into tertiles based on their NAR levels. Cox Proportional Hazards regressions, Kaplan-Meier curves with log-rank tests, and restricted cubic splines were utilized to elucidate the associations between NAR and SAI. Logistic regressions were used to investigate the associations between the poor functional outcome and NAR. To determine the role of SAI in the effect of NAR on the risk of poor functional outcome, mediation analyses were performed. The improvements in model discriminations and calibrations by incorporating NAR into ICH score and max-ICH score were comprehensively explored.
resultsWith each standard deviation increase in NAR after full adjustments, the risks of SAI and poor functional outcome at 3 months rose by 43% and 76%, respectively. Furthermore, incorporating NAR into the ICH score and max-ICH score enhanced both the discrimination and calibration of model performance. Intriguingly, the proportion of the total effect mediated was 9.89% and 10.25% for poor functional outcome at 3 months (
conclusionElevated NAR is a superior biomarker capable of predicting SAI and poor functional outcome after sICH. The association between NAR and the functional outcome is mildly yet significantly mediated by SAI.
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