ArticleAdvanced healthcare materials2026
Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women's cerebrovascular health.Science advances · 2026Review
- In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs.Advanced healthcare materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This study investigates how geometrical variations in volumetrically printed (Vol3DP) structures influence the attachment, survival, and organization of human umbilical vein endothelial cells (HUVECs) and osteosarcoma cells (143b). A gelatin methacryloyl-poly(ethylene glycol) diacrylate (GelMA-PEGDA) resin was optimized for volumetric bioprinting. Compared to GelMA, Gel-PEG enhanced printing fidelity, mechanical properties, and dimensional stability. Disc-like constructs and channels with straight or angled geometries (60°, 90°, 110°) were fabricated and cultured with both cell types for up to 14 days. Label-free holographic microscopy allowed real-time visualization of cellular protrusions, critical for adhesion and mechanosensing, without staining, enabling long-term live-cell analysis in 3D constructs. HUVECs adhered, expressed CD31, and exhibited geometry-dependent spreading, reflecting their native mechanosensitivity and alignment during vascular morphogenesis. In contrast, 143b cells spread uniformly, formed dense, geometry-independent aggregates, and showed enhanced growth in Gel-PEG compared to GelMA, consistent with their aggressive, metastatic behavior. These findings demonstrate that Gel-PEG provides a stable, biomimetic matrix suitable for high-resolution Vol3DP and that holographic microscopy enables dynamic assessment of cell-material interactions. Together, they underscore the potential of this approach for engineering vascularized tissue models and for studying mechanobiological responses in both endothelial and cancer cell systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.