SynthesisCNS & neurological disorders drug targets2026
Impact of Structured Physical Exercise on Adolescent Depression: A Comprehensive Meta-Analysis of RCTs.
Synthesis in CNS & neurological disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Aerobic exercise for depression symptoms in adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough research supports the benefits of Physical Exercise (PE) in treating adolescent depression, data remain limited regarding the most effective types, durations, and intensities of exercise. Moreover, most of the research conducted has focused on short-term outcomes, leaving a notable gap in understanding the long-term sustainability of these benefits. Evaluate the effectiveness of PE in alleviating depressive symptoms in adolescents diagnosed with major depressive disorder (CRD number: CRD42024585812).
methodsThe search was conducted from inception to July 2024 in the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, and SPORTDiscus. Randomized Controlled Trials (RCTs) involving adolescents aged 10-19 years diagnosed with unipolar major depression were included. The intervention group participated in structured PE programs, whereas the control group did not have PE. Two authors independently conducted screening, data extraction, and risk of bias assessment. A data synthesis was performed using a random-effects model to calculate the Standardized Mean Differences (SMD) for continuous outcomes. Heterogeneity was assessed using the I2 statistic. Sensitivity and subgroup analyses were used to explore the effects of different PE modalities and the duration and intensity of the interventions.
results13 RCTs: 759 adolescents in the PE group and 695 in the control group were obtained. PE significantly reduced depressive symptoms compared to the control (SMD=-0.55; p<0.01; I DISCUSSION: PE demonstrates considerable potential as an adjunctive strategy to pharmacological treatment for depression, suggesting its impact may be further enhanced when implemented alongside pharmacotherapy.
conclusionPE, aerobic exercise, and resistance training are effective interventions for reducing depressive symptoms in adolescents. Moderate-intensity exercise of 30-60 minutes offers substantial benefits.
Indexed as
Identifiers
41185515What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.