ReviewMini reviews in medicinal chemistry2026
Advances in 4-Hydroxycoumarin Chemistry: Functionalization, Prominent 4-Hydroxycoumarin-based Therapeutics and their Pharmacological Significance.
Review in Mini reviews in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis review discusses recent advances in 4-hydroxycoumarin (4-HC) and its derivatives, emphasising its promise as a versatile pharmacological agent with diverse bioactivities.
introduction4-Hydroxycoumarin (4-HC) represents a pivotal heterocyclic compound widely recognized in medicinal and pharmaceutical chemistry, serving as a central scaffold for the development of various therapeutic agents. The derivatives of 4-HC have garnered considerable attention due to their broad range of pharmacological activities, including antibacterial, antiviral, antifungal, anti-inflammatory, and anticancer effects.
methodsThis review employs a combined bibliosemantic and analytical approach, utilizing major bibliographic databases and specialized chemical repositories to extract, categorize, and evaluate relevant studies on 4-HC derivatives. Emphasis is placed on literature from 2018 onwards.
resultsThe review presents a systematic overview of structurally diverse 4-HC derivatives, elucidating the synthetic strategies employed for their functionalization. Their pharmacological profiles are critically examined across distinct therapeutic domains. Structurally and mechanistically relevant analogues, such as clinically established anticoagulants, are highlighted. The derivatives are discussed according to their primary bioactivities to ensure clarity and prevent redundancy. DISCUSSION: The study highlights 4-HC as an important scaffold in medicinal chemistry. Structural adaptability and functionalization enable the synthesis of derivatives with targeted pharmacological effects. While significant advancement has been made, further investigation into structure-activity relationships and mechanistic insights will improve the rational design of next-generation therapeutics.
conclusion4-Hydroxycoumarin and its derivatives exhibit substantial promise as lead scaffolds in drug discovery. Their structural adaptability and diverse biological targets position them as valuable candidates for generating novel therapeutic agents across multiple disease spectra.
Indexed as
Identifiers
41185509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.