Evidence map›Paper›PMID 41185464›Full record

ArticleCell proliferation2026

p75NTR Promotes Circadian-Driven Mineralization During Tooth Development via CK2/PER2 Pathway.

Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manzhu ZhaoCollege of Stomatology, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0008-6779-5000
Hongyan YuanCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Di WangCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Meng LiCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Bo XieCollege of Stomatology, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-4355-0817
Xuqiang ZouDepartment Orthodontics, Hospital of Stomatology, Southwest Medical University, Luzhou, China.
Mingjie LuDepartment Orthodontics, Hospital of Stomatology, Southwest Medical University, Luzhou, China.
Ye QiuCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Jinlin SongCollege of Stomatology, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-0224-6640

Funding

The National Natural Science Foundation of China 82000997The Natural Science Foundation of Chongqing of China cstc2020jcyj-msxmX0018
6 · The paper itself

Abstract

Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles. However, its regulatory mechanisms in tooth development remain incompletely understood. Here, we investigated the role of the p75 neurotrophin receptor (p75NTR) in circadian rhythm regulation and daily mineralization during tooth development using immunofluorescence, circadian rhythm tracking, and genetic models. Spatiotemporal analysis of rat dental germs revealed that oscillatory expression patterns of p75NTR closely aligned with clock genes (Bmal1, Clock, Per1, Per2), mineralization-related factors, and odontogenesis-related factors. p75NTR knockout mice (p75NTR

Indexed as

Casein Kinase IICircadian RhythmOdontogenesisPeriod Circadian ProteinsReceptors, Nerve Growth FactorToothAnimalsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsRatsRats, Sprague-DawleyReceptors, Growth FactorSignal TransductionCasein Kinase IINerve Tissue ProteinsNgfr protein, ratPer2 protein, mousePeriod Circadian ProteinsReceptors, Growth FactorReceptors, Nerve Growth Factorcasein kinase 2circadian rhythmp75 neurotrophin receptorphosphorylationtooth development

Identifiers

PMID41185464
PMCPMC13114795

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.