Evidence map›Paper›PMID 41185411›Full record

ArticleThe Journal of physiology2026

Deletion of the TRPV1 channel attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure.

Jacob B Sullivan, Leon J DeLalio, Sean D Stocker

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob B SullivanDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0009-0000-9525-5345
Leon J DeLalioDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9251-0109
Sean D StockerDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6317-6300

Funding

Forebrain electroneutral transporters in salt-sensitive hypertensionR01HL163906 · NHLBI · UNIVERSITY OF DELAWARE · PI SEAN D STOCKER, Megan M Wenner · 2023 to 2026
$2.8M
Autonomic control of kidney functionR01DK135541 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SEAN D STOCKER, Mark L. Zeidel · 2023 to 2026
$2.6M
Identification of mechano versus chemo-sensitive renal sensory neurons in hypertensionR01HL152680 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2020 to 2023
$2.4M
Functional and molecular identity of renal sensory nerves in hypertensionF32DK123994 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELALIO, LEON JOSEPH · 2019 to 2022
$181k
Role of TRPV1 renal sensory nerves in chronic kidney diseaseK99DK133561 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELALIO, LEON JOSEPH · 2022 to 2022
$92k
Alpha1-adrenergic Pannexin 1 activation is mediated by Src family kinasesF31HL137270 · NHLBI · UNIVERSITY OF VIRGINIA · PI DELALIO, LEON JOSEPH · 2017 to 2018
$49k
NHLBI NIH HHS F31 HL137270NHLBI NIH HHS R01 HL152680NHLBI NIH HHS R01 HL163906NIDDK NIH HHS F32 DK123994NIDDK NIH HHS K99 DK133561NIDDK NIH HHS R01 DK135541
6 · The paper itself

Abstract

Renal sensory neurons widely express the transient receptor potential vanilloid type 1 (TRPV1). TRPV1 is a non-selective cation channel responsive to mechanosensitive stimuli, temperature, pH and various chemical factors. The present study tested whether TRPV1 channels contribute to afferent renal nerve activity (ARNA) responses during renal artery occlusion, renal ischaemia and increased renal pelvic pressure using a Trpv1

Indexed as

KidneyKidney PelvisNeurons, AfferentRenal ArteryTRPV Cation ChannelsAnimalsBlood PressureFemaleMaleRatsRats, Sprague-DawleyRenal CirculationTrpv1 protein, ratTRPV Cation Channelsafferentchemoreceptorischaemiamechanoreceptorocclusionpelvic pressureTRPV1

Identifiers

PMID41185411
PMCPMC12871925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.