Evidence map›Paper›PMID 41185406›Full record

ArticleAnimal models and experimental medicine2025

Refining the Sox10

Chaoting Lan, Jiazhang Chen, Shenwei Huang, Yide Mu, Qiuhua Wang, Xin Zhong, Ning Tang, Xinying Zhao, Jieting Lu, Yuxin Wu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Refining the Sox10Animal models and experimental medicine · 2025
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chaoting LanGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.ORCID 0000-0002-6363-9587
Jiazhang ChenDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Shenwei HuangDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Yide MuDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Qiuhua WangGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.
Xin ZhongGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.
Ning TangGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.
Xinying ZhaoDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Jieting LuDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Yuxin WuDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Lihua HuangDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Jixiao ZengDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Wei ZhongDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Yu OuyangGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.
Qiuming HeGuangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou, China.
Yan ZhangDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.

Funding

Basic and Applied Basic Research Foundation of Guangxi Province of China 2025GXNSFBA069072Medical Scientific Research Foundation of Guangdong Province of China A2024374National Natural Science Foundation of China 81970450National Natural Science Foundation of China 82070528National Natural Science Foundation of China 82170528National Natural Science Foundation of China 82200561National Natural Science Foundation of China 82201893National Natural Science Foundation of China 82301955National Natural Science Foundation of China 82370526National Natural Science Foundation of China 82560108Science and Technology Projects in Guangzhou 202201020006The Guangdong Basic and Applied Basic Research Foundation 2024A03J1171The Guangdong Basic and Applied Basic Research Foundation 2024A03J1238The Guangdong Basic and Applied Basic Research Foundation 2024A1515013190
6 · The paper itself

Abstract

backgroundThe traditional Sox10

methodsWe select the offspring from mating B6C3Fe Sox10

resultsSanger sequencing results show that the mutation sites of B6C3Fe and B6C3Fe-g mice are consistent. After fluorescent staining of intestinal nerves, it was found that the heterozygous mice of the two strains had neuronal deletion in the distal colon, and this pathological phenotype was consistent with the pathological features of the diseased colon of Hirschsprung disease (HSCR). However, compared with the B6C3Fe strain, the B6C3Fe-g strain has a higher number of offspring and greater survival rates.

conclusionsThe breeding strategy of the B6C3Fe-g strain ensures genetic and phenotypic stability, while improving reproductive efficiency, and is an ideal scheme for breeding Sox10

Indexed as

BreedingDisease Models, AnimalHirschsprung DiseaseSOXE Transcription FactorsAnimalsFemaleMaleMiceMice, Inbred C57BLMutationPhenotypeSox10 protein, mouseSOXE Transcription FactorsB6C3Fe6B6C3Fe‐gHirschsprung diseaseSox10

Identifiers

PMID41185406
PMCPMC12660488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.