ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026
Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Myeloid Cell-Specific Retinoid X Receptor Signaling Facilitates White Matter Repair and Stroke Recovery in Aged Mice.Stroke · 2026Article
- TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke.Acta pharmacologica Sinica · 2026Article
- Microglia-Mediated Vascular Network Remodeling After Ischemic Stroke: An Immunovascular Repair Framework.Cells · 2026Review
- Skimmianine Pretreatment Attenuates Cerebellar Neuroinflammation and Myelin Injury Following Experimental Cerebral Ischemia-Reperfusion.Antioxidants (Basel, Switzerland) · 2026Article
- Microglia-vascular interactions after spinal cord injury: regulatory mechanisms and therapeutic advances.Frontiers in immunology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural network connections require adequate blood flow to deliver sufficient oxygen and glucose. Acute ischemic stroke (AIS) significantly impairs neural function due to insufficient blood flow, leading to diffuse microvascular dysfunction and compromised white matter integrity, both indicators of poor prognosis. Post-stroke neural recovery hinges on promoting neovascularization around the infarct and restoring white matter integrity. Therefore, strategies to enhance angiogenesis and white matter repair are crucial for post-stroke neuro-rehabilitation. Emerging research highlights the pivotal roles of activated microglia, astrocytes, and oligodendrocyte precursor cells in facilitating neurogenesis, angiogenesis, and neural functional recovery following cerebral ischemia. In this review, we explore the mechanisms by which these neuroglial cells contribute to angiogenesis and white matter repair after AIS. We also propose potential therapeutic strategies that target the intricate interactions at the glial cell-endothelial cell interface. A deeper understanding of oligovascular signaling in ischemic conditions could unveil novel therapeutic targets for improving outcomes after AIS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.