Evidence map›Paper›PMID 41185057›Full record

ArticleActa neuropathologica communications2025

Diffusely metastatic glioblastoma with FGFR3::TACC3 fusion: cell-free DNA fragmentation analyses and molecular characterization of matched primary and metastatic tumor sites.

Miguel A Hernandez-Rovira, Alicia Vagnozzi, Tyler Bales, Keerthana N Prabhu, Noushin Niknafs, Milan Chheda, Jiayi Huang, Albert H Kim, Michelle Miller-Thomas, Omar Butt and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Miguel A Hernandez-Rovira *School of Medicine, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Alicia Vagnozzi *Department of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Tyler BalesSchool of Medicine, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Keerthana N PrabhuTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Noushin NiknafsSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Milan ChhedaDivision of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Jiayi HuangDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Albert H KimTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Michelle Miller-ThomasDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Omar ButtDivision of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Katie D VoDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bhargavi S SovaniDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ashwin Singh PariharSiteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Suzanne CrumleyDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Sonika DahiyaDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Dimitrios MathiosTaylor Family Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, 63110, USA. mathios@wustl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracranial metastasis of IDH-wildtype glioblastoma is very rare and poorly understood at the molecular level. We report a case of FGFR3::TACC3 fusion IDH-wildtype glioblastoma in a 61-year-old male, whose preoperative blood sample showed highly aberrant cfDNA fragmentation patterns, which could be suggestive of early systemic dissemination, undetected by standard-of-care imaging of his body. Eleven months post-resection and adjuvant therapy, he developed widespread extracranial metastases. Comprehensive molecular profiling of matched primary and metastatic tumors revealed broadly conserved genomic, transcriptomic, and copy number landscapes, with the metastasis harboring an additional ERCC6 deletion and enriched expression of receptor tyrosine kinase signaling genes. These findings provide rare insight into the genetic continuity and evolution underlying IDH-wildtype glioblastoma metastasis.

Indexed as

Brain NeoplasmsGlioblastomaMicrotubule-Associated ProteinsReceptor, Fibroblast Growth Factor, Type 3HumansMaleMiddle AgedOncogene Proteins, FusionFGFR3 protein, humanMicrotubule-Associated ProteinsOncogene Proteins, FusionReceptor, Fibroblast Growth Factor, Type 3TACC3 protein, humancfDNAFGFR3::TACC3FragmentationGlioblastomaLiquid biopsyMetastasisSystematic review

Identifiers

PMID41185057
PMCPMC12581515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.