Evidence map›Paper›PMID 41185029›Full record

ArticleBMC biology2025

Genomic signatures of subterranean lifestyle and ecological adaptation in Myospalax.

Na Wan, Jiaqi Chen, Muli Jiang, Mengzhuo Wu, Haolin Li, Mozhi Wen, Wei Shen, Xiaolong Liang, Xiaojie Yang, Yijing Liu and 3 more

Abstract read
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In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Na WanState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Jiaqi ChenState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Muli JiangCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Mengzhuo WuState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Haolin LiSchool of Life Sciences, Lanzhou University, Lanzhou, People's Republic of China.
Mozhi WenState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Wei ShenState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Xiaolong LiangState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Xiaojie YangState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Yijing LiuState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Yige GaoState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China.
Eviatar NevoInstitute of Evolution, University of Haifa, Haifa, 3498838, Israel.
Kexin LiState Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, People's Republic of China. likexin@lzu.edu.cn.

Funding

National Natural Science Foundation of China 32271691)
6 · The paper itself

Abstract

backgroundMammals exhibit diverse adaptations to varied habitats, yet the genomic mechanisms underlying these transitions remain incompletely understood. Here, we present a comparative genomic, epigenomic, and three-dimensional chromatin analysis of two closely related zokor species, Myospalax aspalax and Myospalax psilurus, which inhabit arid and humid subterranean environments, respectively.

resultsWe identified subterranean lineage-specific positively selected and rapidly evolving genes enriched for DNA repair, hypoxia response, blood vessel development, and fructose metabolism. M. psilurus showed a notable loss of olfactory receptor genes, expansion of pheromone-related gene families, and widespread activation of a specific ERVK transposable element family, accompanied by elevated DNA methylation, suggesting enhanced epigenetic defenses and ecological specialization. In contrast, M. aspalax showed selection in kidney and lipid metabolism genes. Large chromosomal inversions (> 1 Mb) overlapped islands of high genetic divergence (high-F

conclusionsOverall, our results illuminate the structural, regulatory, and evolutionary mechanisms underlying ecological divergence and highlight how genome architecture contributes to adaptive evolution in subterranean mammals.

Indexed as

Adaptation, PhysiologicalEcosystemGenomeAnimalsGenomicsChromatin contactsDNA methylationHygrothermalInverted repeatsLarge inversionNon-allelic homologous recombinationSubterraneanTransposable element

Identifiers

PMID41185029
PMCPMC12581442

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