ArticleJournal of nanobiotechnology2025
A trimer ancestral spike-based mRNA vaccine confers cross-generational protection against SADS-CoV.
Teng Zhang, Jiale Yao, Xinchun Guo, Chaoliang Leng, Saige Liu, Yaxin Chen, Jucai Wang, Mengsi Sun, Hongfu Ma, Longfa Li and 4 more
Abstract read
In one paragraphArticle in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Teng Zhang *Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.ORCID http://orcid.org/0000-0001-8530-5732 Jiale Yao *Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.ORCID http://orcid.org/0009-0006-5889-730X Xinchun GuoHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.ORCID http://orcid.org/0009-0003-8915-6262 Chaoliang LengHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.
Saige LiuHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.ORCID http://orcid.org/0009-0005-0902-2059 Yaxin ChenHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.
Jucai WangCollege of Food and Drug, Luoyang Normal University, Luoyang, 471934, China.
Mengsi SunInstitute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, 518000, Guangdong, China.
Hongfu MaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Longfa LiHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China.ORCID http://orcid.org/0009-0002-4150-5147 Yong WangCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China. wangyong119@ahau.edu.cn.
Gaiping ZhangLonghu Laboratory, Zhengzhou, China. zhanggaip@126.com.
Lunguang YaoHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, College of Life Science, Nanyang Normal University, Nanyang, 473000, Henan, China. lunguangyao@nynu.edu.cn.ORCID http://orcid.org/0000-0003-4059-1100 Funding
Key Scientific Research Projects of Colleges and Universities in Henan Province of China No. 23A230002National Natural Science Foundation of China No. 32402887Scientific and Technological Research Project of Henan Province No. 242102110051
6 · The paper itselfAbstract
The emergence of coronavirus variants that evade vaccine protection poses a serious threat to both human health and animal husbandry, including the novel SADS-CoV, an emerging bat-derived coronavirus. Herein, we introduce a "phylogenetic antigen reconstruction" strategy to design a trimeric ancestral spike (
Indexed as
Spike Glycoprotein, CoronavirusViral VaccinesAnimalsAntibodies, ViralChickensCross ProtectionFemaleHumansMiceMice, Inbred BALB CmRNA VaccinesRNA, MessengerSwineVaccines, SyntheticAntibodies, ViralmRNA VaccinesRNA, MessengerSpike Glycoprotein, CoronavirusVaccines, SyntheticViral VaccinesAncestral phylogeneticSADS-CoVSpike proteinTrimer mRNA vaccine
Identifiers
PMID41185028
PMCPMC12584437
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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