ReviewCell communication and signaling : CCS2025
Neutrophils and neutrophil extracellular traps: double-edged swords in cancer pathophysiology and therapy resistance.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting.Molecular biomedicine · 2026Review
- Roles of neutrophil extracellular traps in cancer immunotherapy resistance and therapeutic targeting.Biomarker research · 2026Review
- Development and validation of a biopsy-based model using tumor-associated neutrophils to predict neoadjuvant chemotherapy response in osteosarcoma: a large single-center retrospective cohort study.Journal of bone oncology · 2026Article
- Nature meets immunity: curcumin's role in modulating neutrophil extracellular traps.Inflammopharmacology · 2026Review
- Integrated multi-omics analysis of neutrophil extracellular trap-related genes in renal cell carcinoma using bioinformatics and machine learning.Discover oncology · 2026Article
- Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal transduction and targeted therapy · 2026Review
- The immunosuppressive tumor microenvironment in glioblastoma.Frontiers in immunology · 2026Review
- Neutrophil Extracellular Traps in Pancreatic Ductal Adenocarcinoma: A Vicious Cycle in the Tumor Microenvironment and Targeted Interventions.International journal of biological sciences · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
Among white blood cells (WBCs), neutrophils are the most abundant and multifunctional immune cells in the blood, which are also involved in diverse physiological and pathological processes, particularly affecting the deterioration of the tumor. Neutrophil extracellular traps (NETs), composed of chromatin DNA studded with granule proteins, play a crucial role in reactive sterile inflammation. Recently, neutrophils have garnered focus in cancer research due to their participation in cancer initiation, proliferation and metastasis. As important players in the tumor microenvironment (TME), tumor-associated neutrophils (TANs) are viewed as “a double-edged sword” in cancer pathophysiology.In this review, we introduce the NETs formation and associated signaling pathways. Meanwhile, recent studies on the mechanisms through by which neutrophils could promote tumors development will be described. Additionally, we outline the complex complicated molecular mechanisms underlying cancer therapy resistances and associated preface tumor treatment. Finally, we highlight latest advances in NETs-targeting treatment strategies designed to improve the efficacy of cancer therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.