Trial reportBMC oral health2025
Effectiveness of curcumin mouthwash in preventing traumatic ulcers in orthodontic patients.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05147376 (Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances: a Randomized Clinical Trial
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundOrthodontic treatment can cause traumatic ulcers within the first month due to friction and irritation. Curcumin, a turmeric extract, exhibits analgesic, anti-inflammatory, antibacterial, and wound-healing properties. This study investigated the effectiveness of curcumin mouthwash in preventing traumatic ulcers in fixed orthodontic patients during the first month of treatment.
methodsIn this double-blind, placebo-controlled, randomized clinical trial, 70 patients aged 12-30 years were assigned to curcumin or placebo mouthwash, used twice daily for 28 days after bracket cementation. Primary outcomes were (1) incidence and (2) duration of traumatic ulcers. Secondary outcomes included pain scores, ulcer sites, adverse effects, plaque index (PI), gingival index (GI), gingival bleeding index (GBI), and patient feedback. Data were analyzed using descriptive statistics and SPSS software.
resultsAll 70 patients completed the trial, with 35 participants in the curcumin group (mean age 20.88 ± 4.87 years) and 35 in the placebo group (mean age 18.60 ± 4.20 years). No significant between-group differences were observed in the incidence or duration of traumatic ulcers (p > 0.05). Patients in the curcumin group reported significantly lower pain scores compared with those in the placebo group during the first and second weeks (p < 0.05), indicating an early analgesic effect; however, no significant differences were observed thereafter. The buccal mucosa was the most frequent ulcer site, and orthodontic wax use did not differ significantly between groups (p > 0.05). No adverse effects were reported in the curcumin group, and participants rated its smell as more pleasant. Baseline PI was lower in the curcumin group (p < 0.05), but no post-intervention differences were observed (p > 0.05). Within-group analyses showed a PI reduction in the placebo group and a GI reduction in the curcumin group (both p < 0.05), while GBI remained unchanged.
conclusionsAlthough ulcer prevention was not observed, curcumin mouthwash may serve as an adjunct for early pain relief in orthodontic patients.
trial registrationClinicalTrials.gov (Identifier: NCT05147376), registered on December 7, 2021. Available at: https://clinicaltrials.gov/study/NCT05147376 .
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