ArticleWorld journal of surgical oncology2025
Time to surgery in patients with colorectal liver metastases.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The impact of time-to-recurrence on post-recurrence mortality in stage I-III colorectal cancer: A nationwide Danish cohort study.International journal of cancer · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical resection and locoregional therapies are crucial for the curative treatment of colorectal liver metastases (CRLM). The impact of time to surgery on long-term survival is unclear. Evidence from other hepatobiliary cancers suggests surgical delays do not adversely affect outcomes. We aimed to investigate the impact of time between treatment referral and surgical intervention on overall survival in patients with CRLM. We also sought to identify clinical predictors of time to surgery.
methodsThis nationwide study included patients with CRLM between March 2013 and December 2023 in Denmark. Multivariable Cox proportional hazards models examined the association between time to surgery and mortality risk. Kaplan-Meier estimators described long-term survival. Linear regression identified clinical predictors of the time between referral and surgery.
resultsAmong 2732 patients included, the median time to surgery was 28 days. Unadjusted analysis indicated a 3% increase in mortality per additional week from referral to surgery (hazard ratio (HR) 1.03, 95% CI 1.01-1.05). However, adjusted analyses did not confirm this association (HR 1.02, 95% CI 0.99-1.05). Five-year survival did not differ significantly between patients treated within 28 days and those after. More than one multidisciplinary team conference held before surgery were associated with longer time to surgery.
conclusionsTime to surgery has little effect on survival and mortality risk in CRLM patients. Additional waiting time associated with multiple MDT conferences likely reflect necessary preoperative optimization. Further research is needed in populations without fast-track cancer pathways.
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