ArticleBMC psychiatry2025
Effects of sleep quality on the default mode network and on anxiety-depression symptoms in premenstrual syndrome.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundNeuroimaging studies indicate a link between the aberrant default mode network (DMN) and anxiety-depression severity in premenstrual syndrome (PMS); however, ignoring the effects of sleep prevents understanding the pathophysiology of PMS.
methodsSeventy-seven PMS patients and sixty-six healthy controls (HCs) underwent resting-state functional MRI, and clinical assessment included the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale. PSQI scores classified PMS patients into normal sleep quality (PMS-NSQ) and poor sleep quality (PMS-PSQ) groups. Resting-state functional connectivity (rsFC) within the DMN were compared among the three groups. Correlation and mediation analyses examined potential associations relating sleep quality, changes in brain function, and clinical variables.
resultsCompared to HCs, both PMS-PSQ and PMS-NSQ groups exhibited increased rsFC between left inferior parietal lobule (IPL) and right middle occipital gyrus. Additionally, the PMS-NSQ group presented decreased FC of right ventromedial prefrontal cortex (VMPFC) and right posterior cingulate/precuneus (PCu), as well as lower degree centrality of right VMPFC. Combined correlation and mediation analyses showed that the relationship between the altered FC of right VMPFC-right PCu and anxiety-depression symptoms was mediated by sleep quality in PMS patients.
conclusionsThe findings reveal the potential neuropathology of sleep problems in PMS, which sleep quality may mediate the association between FC within DMN and anxiety-depression severity. The right VMPFC may prospectively serve as potential intervention targets for the treatment of sleep disturbances in PMS.
trial registrationThis study was registered in the Chinese Clinical Trial Registry (ChiCTR1900020642, https//www.chictr.org.cn) on 11th Jan 2019.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.