Evidence map›Paper›PMID 41184954›Full record

ArticleJournal of ovarian research2025

One-carbon metabolism and risk of PCOS: insights from Mendelian randomization.

Yifan Zhao, Gaochen Zhang, Jiexue Pan, Hefeng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yifan Zhao *International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Gaochen Zhang *Institute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.
Jiexue PanInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China. panjiexue@fudan.edu.cn.
Hefeng HuangInternational Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. huanghefg@fudan.edu.cn.

Funding

Key Discipline Construction Project (2023-2025) of Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai GWVI-11.1-35National Natural Science Foundation of China 82088102, 82171688Shanghai Clinical Research Center for Gynecological Diseases 22MC1940200Shanghai Urogenital System Diseases Research Center 2022ZZ01012
6 · The paper itself

Abstract

backgroundAbnormal one-carbon metabolism has been reported by observational studies to contribute to an increased risk of polycystic ovary syndrome (PCOS) and undesirable reproductive outcomes in women with PCOS. However, the underlying causal associations remain uninvestigated. This study aims to assess the independent causal links between essential substrates, enzymes and cofactors involved in one-carbon metabolism and PCOS, using bidirectional two-sample Mendelian randomization (MR) and Multivariable MR.

resultsGenetically predicted high levels of folate (OR = 2.92; 95% CI, 1.81 - 3.98; P = 8.32 × 10

conclusionsThis study integrates metabolomics and genomics to evaluate the causal effects of genetically determined one-carbon metabolism-related factors on PCOS risk, highlighting the critical role of one-carbon metabolism in maintaining reproductive health. These findings underscore the potential of targeting one-carbon metabolism for the prevention and management of PCOS, offering new avenues for clinical interventions. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

CarbonPolycystic Ovary SyndromeAdultFemaleFolic AcidHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsCarbonFolic Acid5,10-methylenetetrahydrofolate reductaseFolate; one-carbon metabolismMendelian randomizationPolycystic ovary syndrome

Identifiers

PMID41184954
PMCPMC12581609

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.