ArticleBMC medicine2025
Dynamic excitation/inhibition balance preceding seizure onset and its link to functional and structural brain architecture.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome.Biological psychiatry global open science · 2026Article
- Periodic and aperiodic components during shooting preparation and pre-/post-task resting states: a spectral parameterization study.Experimental brain research · 2026Article
- Review
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- Lateralized excitation-inhibition rebalance correlates with motor recovery following hemispheric surgery.Brain communications · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- A Translational Platform for Polyimide Neural Interfaces: Polyimide Synthesis and in Vivo Evaluation in Epileptic Mice.IEEE access : practical innovations, open solutions · 2026Article
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9 authors.
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Abstract
backgroundAltered excitation/inhibition (E/I) balance is a key mechanism in epilepsy, but its dynamic changes before seizure onset remain unclear. The interictal suppression hypothesis suggests that inhibitory input isolates epileptic regions, yet little is known about E/I dynamics in the pre-ictal phase.
methodsWe analyzed high-density EEG recordings from patients with drug-resistant focal epilepsy, each with at least one recorded seizure. Cortical activity was reconstructed using source modeling, and time-resolved changes in the aperiodic exponent-a non-invasive marker of E/I balance-were computed. Directed functional connectivity was assessed via spectral Granger causality. These metrics were correlated with cortical thickness and neurotransmitter receptor density maps.
resultsThe aperiodic exponent increased progressively in the minutes preceding seizures, reflecting a global shift toward cortical inhibition, with no significant differences between epileptic and non-epileptic regions. Delta and theta power also increased preictally. Epileptic regions showed significantly more outward than inward connectivity, and more outward connectivity than non-epileptic areas. In non-epileptic regions, higher inhibition was associated with greater outward connectivity. Cortical thickness positively correlated with inhibition only in non-epileptic areas. Lower muscarinic receptor density was associated with stronger inhibitory shifts.
conclusionsSeizure onset is preceded by a widespread shift toward inhibition, possibly representing a compensatory mechanism that fails as ictal thresholds are crossed. This shift is linked to altered connectivity and disrupted structure-function coupling in epileptic regions. The dynamic aperiodic exponent emerges as a promising biomarker for seizure prediction and a potential target for neuromodulation strategies.
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