Trial reportBMC oral health2025
The effect of enzyme and protein containing toothpaste on gingival condition: a randomised controlled study.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06932211 (A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulation of dental plaque can lead to gingival problems. A fluoride toothpaste containing naturally occurring enzymes and proteins has been shown to improve gingival health and reduce supragingival plaque in European populations. The objective of the current study was to evaluate the ability of this toothpaste to improve gingival condition and reduce supragingival plaque in an alternative study population.
methodsThis was a double-blind (participant, examiner, investigator, statistician), randomised, parallel group, efficacy study conducted at a Chinese university dental hospital. Participants (age 18-70) with a mean Gingival Index (GI) ≥ 1.0 and mean Modified Quigley and Hein Plaque Index (MQHPI) ≥ 1.5 were randomised at baseline using sex stratification to twice-daily brushing with either test toothpaste (n=127) or control fluoride toothpaste (n=124) for 26 weeks. Assessments of GI (primary outcome) and MQHPI were conducted at baseline and after 4, 13 and 26 weeks of product use. Results were analysed using ANCOVA model for between product comparison (α= 0.05).
resultsOne hundred and six participants using test toothpaste and 92 using control toothpaste completed the study. The test toothpaste showed significantly greater improvements in gingival health than the control toothpaste. The estimated differences in GI between groups were -0.18 (95% CI: -0.23 to -0.12) at week 4, -0.16 (95% CI: -0.20 to -0.11) at week 13, and -0.53 (95% CI: -0.60 to -0.46) at week 26 (all p < 0.0001). Similarly, reductions in supragingival plaque were greater in the test group, with differences in MQHPI of -0.29 (95% CI: -0.38 to -0.21) at week 4, -0.35 (95% CI: -0.45 to -0.25) at week 13, and -0.96 (95% CI: -1.06 to -0.85) at week 26 (all p < 0.0001).
conclusionsThe study demonstrated that a toothpaste containing naturally occurring enzymes and proteins significantly improved gingival health and reduced supragingival plaque compared to a control toothpaste, after 4, 13, and 26 weeks of use. CLINICAL
trial registrationNCT06932211 (retrospectively registered on April 17, 2025).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.