Evidence map›Paper›PMID 41184906›Full record

ReviewJournal of nanobiotechnology2025

Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms.

Hina Singh, Sri Renukadevi Balusamy, Johan Sukweenadhi, Muthupandian Saravanan, Mohanprasanth Aruchamy, Ivan Mijakovic, Priyanka Singh

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. The hallmarks of host-microbiome decoupling.Frontiers in microbiology · 2026
    Review
  17. Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hina Singh *Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, 92521, USA. Hina.Singh@medsch.ucr.edu.
Sri Renukadevi Balusamy *Department of Food Science and Biotechnology, Sejong University, Gwangjin-Gu, Seoul, 05006, Republic of Korea.
Johan SukweenadhiFaculty of Biotechnology, University of Surabaya, Raya Kalirungkut, Kalirungkut, Surabaya, 60293, Indonesia.
Muthupandian SaravananPrince Fahad bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, 71491, Saudi Arabia.ORCID http://orcid.org/0000-0002-1480-3555
Mohanprasanth AruchamyAMR & Nanotherapeutics Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 600 077, India.ORCID http://orcid.org/0000-0001-9008-0814
Ivan MijakovicThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, 2800, Denmark. ivan.mijakovic@chalmers.se.
Priyanka Singh *The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, 2800, Denmark. prisin@biosustain.dtu.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds remain a persistent clinical challenge due to their complex pathology involving prolonged inflammation, microbial biofilms, and impaired tissue regeneration. Emerging research highlights the dynamic role of the human microbiome in modulating immune responses and influencing wound healing outcomes. Disruptions to this microbial balance, termed dysbiosis, not only exacerbate infection but also hinder therapeutic efficacy. Recent advances in smart and sustainable nanotechnology offer promising avenues to address these challenges. By integrating microbiome-sensitive mechanisms with targeted delivery systems, bio-based nanomaterials can overcome multidrug resistance, modulate inflammation, and accelerate healing. This review explores the molecular interplay between chronic infections and host immunity, highlights next-generation nanomaterials for regenerative applications, and proposes a sustainable paradigm that bridges clinical effectiveness with environmental responsibility.

Indexed as

MicrobiotaNanostructuresAnimalsBiofilmsChronic DiseaseDysbiosisHumansNanotechnologyWound HealingArtificial intelligenceChronic infectionsMicrobiome therapyPersonalized medicineSmart hybrid nanomaterialsSustainable nanomaterials

Identifiers

PMID41184906
PMCPMC12581504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.