Evidence map›Paper›PMID 41184871›Full record

ReviewBMC pediatrics2025

Esophageal atresia with concomitant hypertrophic pyloric stenosis: a case series and literature review.

Zhaozhou Liu, An Wang, Dingding Wang, Yong Zhao, Yanan Zhang, Shuangshuang Li, Junmin Liao, Kaiyun Hua, Yichao Gu, Dayan Sun and 1 more

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaozhou Liu *Department of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
An Wang *Department of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Dingding WangDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Yong ZhaoDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Yanan ZhangDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Shuangshuang LiDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Junmin LiaoDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Kaiyun HuaDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Yichao GuDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Dayan SunDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.
Jinshi HuangDepartment of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China. hjsbch@163.com.

Funding

Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park Z211100002921062Natural Science Foundation of Beijing Municipality 7252043
6 · The paper itself

Abstract

backgroundEsophageal atresia (EA) with concomitant hypertrophic pyloric stenosis (HPS) is a rare condition, and its diagnosis can be challenging due to overlapping postoperative complications. Comprehensive clinical characterization remains limited.

methodsWe retrospectively reviewed five patients with EA with concomitant HPS treated at our center between 2018 and 2025. A systematic literature search of PubMed, Embase, Web of Science, and CNKI identified 48 additional cases. Clinical features, timing of diagnosis, treatment strategies, and outcomes were analyzed.

resultsAmong 132 neonates with EA in our institution, five (3.8%) developed HPS. Four had Gross type C EA, and three were male. All underwent EA repair in the first week of life and later developed HPS, diagnosed at a median age of 45 days (range: 20-145). All patients underwent laparoscopic pyloromyotomy with uneventful recovery and were alive at a median follow-up of 50 months. Literature review revealed 48 reported cases, predominantly male (41/48) and Gross type C (42/48). Combined analysis of 53 patients showed HPS onset typically between 2 and 15 weeks, with a median age of 4 weeks (IQR: 2.5-6 weeks). Overall survival was 90.6%, with deaths mainly due to infection or severe associated anomalies.

conclusionsHPS may coexist with EA, with an incidence of approximately 3.8%. It often presents later in the disease course. Its diagnosis can be delayed by postoperative complications or altered feeding. Long-term follow-up and multicenter studies are warranted.

Indexed as

Esophageal AtresiaPyloric Stenosis, HypertrophicFemaleHumansInfantInfant, NewbornMalePyloromyotomyRetrospective StudiesCongenital anomaliesEsophageal atresiaHypertrophic pyloric stenosisPediatric surgery

Identifiers

PMID41184871
PMCPMC12581317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.