Evidence map›Paper›PMID 41184846›Full record

ArticleBMC infectious diseases2025

Mycobacterium tuberculosis-induced oligodendrocyte apoptosis promotes astrocyte-mediated cell-in-cell formation and phagocytosis in tuberculous meningitis.

Jinli Feng, Feng Qiu, Zubiao Niu, Ming Fang, Jianghui Yang, Li Xiao, Jun Zhao, Qiang Sun, Jiatang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinli Feng *Department of Neurology, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Feng Qiu *Department of Neurology, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Zubiao NiuLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Ming FangDepartment of Anesthesiology, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Jianghui YangDepartment of Pathology, Tsinghua Chang Gung Hospital, Beijing, China.
Li XiaoInstitute of Respiratory and Critical Care Medicine, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Jun ZhaoDepartment of Neurology, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Qiang SunLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China. sunq@bmi.ac.cn.
Jiatang ZhangSenior Department of Neurology, The First Medical Center of PLA General Hospital, Beijing, China. zjt1128@aliyun.com.

Funding

Key Project of the Eighth Medical Center of PLA General Hospital No. 2021ZD007the National Natural Science Foundation of China No. 82002918, No. 31970685, No. 31671432
6 · The paper itself

Abstract

objectiveTo determine whether cell-in-cell (CIC) structures exist in tuberculous meningitis (TBM) and to explore their clinical significance.

methodsPathological brain biopsies from TBM patients were retrospectively analyzed using H&E and immunohistochemistry, with a focus on CIC structures. Multicolor immunofluorescence and in vitro coculture of astrocytes and oligodendrocytes were employed to explore CIC characteristics and underlying mechanisms. Flow cytometry was used to assess Bacillus Calmette-Guérin (BCG)-induced oligodendrocyte apoptosis.

resultsCIC structures (CICs) were identified in TBM brain tissues. Astrocytes were confirmed as target cells, while oligodendrocytes and neurons acted as effector cells. Astrocytes engulfed oligodendrocytes both in vivo and in vitro. BCG infection induced oligodendrocyte apoptosis and significantly enhanced CIC formation and phagocytosis. Pretreatment with staurosporine also promoted these processes. CICs observed in TBM primarily resemble internalized types such as phagocytosis.

conclusionMycobacterium tuberculosis-induced oligodendrocyte apoptosis promotes astrocyte-mediated CIC formation and phagocytosis, suggesting CIC as a novel pathophysiological mechanism in TBM.

Indexed as

ApoptosisAstrocytesMycobacterium tuberculosisOligodendrogliaPhagocytosisTuberculosis, MeningealAdultAnimalsBrainFemaleHumansMaleMiddle AgedRetrospective StudiesApoptosisAstrocyteCell-in-cellOligodendrocytePhagocytosisTuberculous meningitis

Identifiers

PMID41184846
PMCPMC12581405

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.