ArticleBMC neurology2025
Preoperative systemic inflammation response index may predict postoperative delayed extubation for elderly patients with aSAH: a retrospective cohort study.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAneurysmal subarachnoid hemorrhage (aSAH) is one common neurosurgical emergency and severe disease, with high morbidity and mortality. Delayed extubation (DE) is a confirmed risk factor for prolonged intensive care unit (ICU) stay and poor outcomes in patients undergoing neurosurgical operation. The systemic inflammation response index (SIRI) has emerged as a novel, valuable prognostic marker for various neoplastic and critical conditions.
objectiveThis study aimed to investigate the association between pre-operative SIRI and post-operative DE in elderly patients underwent neurosurgical clipping or endovascular coiling for aSAH.
methodsWe conducted a retrospective analysis of elderly aSAH patients underwent neurosurgical clipping or endovascular coiling between Jan 2016 and Dec 2022. Patient epidemiologics, clinical variables, and potential influencing factors were assessed. Multivariate logistic regression and receiver operating characteristics (ROC) curve analyses were employed to determine SIRI’s predictive value for DE.
resultsAmong the 413 enrolled patients, 113 patients experienced DE, while 300 patients did not. Multivariate logistic regression analysis identified GCS (OR, 0.631; 95% CI, 0.454–0.879; P = 0.006); lactic dehydrogenase (OR, 1.008; 95% CI, 1.001–1.016; P = 0.042), and SIRI (OR, 1.171; 95% CI, 1.050–1.328; P = 0.006) as independent predictors of DE. ROC curve analysis demonstrated that SIRI effectively predicted postoperative DE (AUC = 0.772, 95% CI, 0.696–0.849, P < 0.001). The optimal SIRI cutoff value was 8.14, yielding a sensitivity of 42.0% and specificity of 95.0%.
conclusionPre-operative SIRI is an independent risk factor for post-operative DE in elderly patients undergoing neurosurgical operation for aSAH.
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