ArticleBMC pediatrics2025
Children with recurrent urinary tract infections: who are they and why do we need better prevention options?
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Prevalence and Antibiotic Resistance Pattern ofInfection and drug resistance · 2026Article
- Nutritional bioactives for preventing recurrent urinary tract infections in children: microbiome-mediated mechanisms and clinical implications.Frontiers in nutrition · 2026Review
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent UTIs (rUTIs) in children can lead to renal scarring and chronic renal failure, if not managed early. The current standard of care involves antibiotic prophylaxis, which benefits remain controversial. There is a need for new interventions, other than antimicrobial use, to reduce the occurrence of rUTIs as well as the identification of groups to target. Our objective was to describe the pediatric population most susceptible to rUTIs, including renal scarring and adverse events associated with prolonged antibiotic use.
methodWe conducted a single-centre retrospective chart review of patients with rUTIs, diagnosed with urinary tract abnormalities or functional disorders, followed at the Centre hospitalier universitaire (CHU) Sainte-Justine urology clinic between January 2015 and December 2020. We described the population and evaluated the antimicrobial usage and uropathogens resistance patterns.
resultsIdentified patients with rUTI (n = 107) had underlying medical conditions such as Spina Bifida or neurogenic bladder (31%), double collecting system (22%), vesicoureteral reflux (42%) and ureteropelvic junction obstruction (7%). Almost all patients (87%) were prescribed antimicrobial prophylaxis, and a significant proportion developed resistance, with 70% of breakthrough UTIs being resistant to at least one drug, and 41% demonstrating multi-drug resistance.
conclusionWhile most patients received prophylaxis, it was not universally effective, leading to persistent concerns like renal scarring and adverse events associated with prolonged antimicrobial use. There is a critical need for the development of new strategies to prevent rUTI that would minimize reliance on antibiotic prophylaxis, given the escalating global threat of antimicrobial resistance.
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