ArticleNeurogastroenterology and motility2025
A Decade of Change: National Trends in Management and Outcomes of Achalasia Hospitalizations in the United States.
Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAchalasia is a rare esophageal motility disorder managed through various interventions, including laparoscopic Heller myotomy (LHM), pneumatic dilation (PD), and, more recently, per-oral endoscopic myotomy (POEM). Over the past decade, there has been a shift toward POEM, though nationwide hospitalization trends and outcomes remain understudied.
methodsWe conducted a retrospective trend analysis using the National Inpatient Sample (NIS) database from 2011 to 2022. Adult patients hospitalized with a primary diagnosis of achalasia were identified using ICD-9/10-CM codes. Trends in management strategies (LHM, POEM, PD, and esophagectomy), hospitalization outcomes, and complications were analyzed. Multivariable regression adjusted for patient and hospital characteristics was also performed to compare outcomes between 2011 and 2022.
resultsA total of 63,420 weighted achalasia-related admissions were identified. The use of LHM declined significantly (AAPC -4.66%, p < 0.001), while POEM use rose from 5.8% in 2016 to 10.3% in 2022 (AAPC 7.76%, p = 0.049). Hospitalization costs increased annually by 3.18% (p < 0.001), while the length of stay remained stable. Mortality rates rose over time; however, there was no difference after adjusting for patient-related factors. Adjusted analyses revealed increased odds of POEM in 2022 (aOR 1.87), decreased odds of LHM and esophagectomy, and higher odds of respiratory complications.
conclusionsFrom 2011 to 2022, there has been a clear shift toward the use of POEM for the inpatient management of achalasia. However, worsening patient comorbidity profiles have driven increased complications and mortality and may contribute to increasing costs. Early intervention and broader POEM adoption may optimize future outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.