Evidence map›Paper›PMID 41184662›Full record

SynthesisAesthetic plastic surgery2026

Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic Review.

Alan Cristian Marinho Ferreira, Lara Raquel Silva, Isabela Espasandin, Julliana Ferreira Sant'Anna, Camila Aniceto Mourão, Andrea Damas Tedesco, Marcelo Germani Vieira, Anna Raphaella Autran Colaço, Rud Machado Varela, Antony de Paula Barbosa

Abstract readSystematic ReviewReview
PubMed Publisher
In one paragraph

Synthesis in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alan Cristian Marinho FerreiraGraduate Program in Public Health, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Lara Raquel SilvaDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil.
Isabela EspasandinDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil.
Julliana Ferreira Sant'AnnaDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil.
Camila Aniceto MourãoDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil.
Andrea Damas TedescoFederal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Marcelo Germani VieiraDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.
Anna Raphaella Autran ColaçoPrivate office, Rio de Janeiro, RJ, Brazil.
Rud Machado VarelaDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil.
Antony de Paula BarbosaDepartment of Research & Development, Antony Barbosa Institute, Belo Horizonte, MG, Brazil. drantonybarbosa@gmail.com.ORCID 0000-0003-2160-3989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCollagen biostimulators, such as poly-L-lactic acid (PLLA) and calcium hydroxyapatite (CaHA), are widely used in facial esthetic treatments to improve skin quality, restore volume, and stimulate neocollagenesis.

objectiveThis study aimed to evaluate the efficacy, durability, and safety of PLLA- and CaHA-based collagen biostimulators in facial esthetic treatments.

methodsA systematic literature review was conducted following PRISMA 2020 guidelines. The PICO strategy guided the research question. Searches were performed in April 2024 in the BVS, Medline (via PubMed), and Scopus databases, using standardized descriptors and Boolean operators. Studies published between 2010 and 2024, available in full text in Portuguese, English, or Spanish, were included. Screening was conducted using the Rayyan platform, and the quality of included studies was assessed with the ROB2 tool.

resultsFourteen studies met the eligibility criteria. Both PLLA and CaHA demonstrated significant improvements in skin elasticity, wrinkle reduction, and increased facial volume. PLLA maintained its effects for up to 25 months, while CaHA offered results lasting 12 to 18 months. The most frequent adverse effects were mild, including pain and swelling at the injection site. One serious case of compression necrosis was reported with CaHA.

conclusionBoth PLLA and CaHA are effective and safe biostimulators for facial rejuvenation. However, further research is needed to standardize techniques and assess long-term safety. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

Indexed as

CollagenCosmetic TechniquesDermal FillersDurapatitePolyestersSkin AgingFaceHumansRejuvenationTreatment OutcomeCollagenDermal FillersDurapatitePolyesterspoly(lactide)Calcium hydroxyapatiteCollagen biostimulatorDurabilityEfficacyPoly-L-lactic acidSafety

Identifiers

PMID41184662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.