ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Target and off-target effects of vibegron on smooth muscle contraction of human detrusor and prostate tissues.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Adrenergic Contraction of Human Prostate Tissues Is Maintained Under the Rab GTPase Inhibitors Nexhinib20 and CID1067700.Pharmacology research & perspectives · 2026Article
- Vibegron for Anticholinergic-Resistant Pediatric Neurogenic Lower Urinary Tract Dysfunction After Spinal Cord Amputation: A Case Report.IJU case reports · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeThe β
methodsDetrusor and prostate tissues were obtained from radical cystectomy, radical prostatectomy and laser enucleation. Concentration response curves for agonists and frequence response curves for electric field stimulation (EFS) were examined in organ baths with 0.01, 0.1, 1 and 10 µM vibegron or vehicle control.
resultsIn detrusor tissues, 10 µM vibegron reduced EFS-induced contractions by half, while no biologically relevant inhibitions occurred with lower concentrations or with carbachol- or methacholine-induced contractions. Pretensions before contractions were relaxed > 20% by 0.1-10 µM vibegron. EFS-induced contractions were halved by 10 µM vibegron in prostatectomized tissues, but unaffected by lower concentrations and in laser-enucleated prostate tissues. Additionally, 10 µM vibegron right-shifted concentration response curves and increased the EC
conclusionsSimilar to mirabegron, improvements of storage symptoms by vibegron involve mechanisms beyond inhibition of voiding contractions. Off-target effects occur with 10 µM, and include inhibition of neurogenic contractions and antagonism of prostatic α
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