Evidence map›Paper›PMID 41184621›Full record

ArticleActa pharmacologica Sinica2026

Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB

Anna Åstrand, Emiliano Laudadio, Prince S Gameli, Laura Martin, Jeremy Carlier, Francesco P Busardò, Johan Dahlén, Xiongyu Wu, Peter Konradsson, Svante Vikingsson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna ÅstrandDivision of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE 581 85 Linköping, Sweden. anna.astrand@liu.se.ORCID http://orcid.org/0000-0001-7486-7537
Emiliano LaudadioDepartment of Science and Engineering of Matter, Environment and Urban Planning, Polytechnic University of Marche, Ancona, Italy.ORCID http://orcid.org/0000-0002-8053-6539
Prince S GameliDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.ORCID http://orcid.org/0009-0001-3194-3250
Laura MartinDivision of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE 581 85 Linköping, Sweden.
Jeremy CarlierDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.ORCID http://orcid.org/0000-0003-3332-9518
Francesco P BusardòDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.ORCID http://orcid.org/0000-0002-3082-4532
Johan DahlénDepartment of Physics, Chemistry and Biology, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0002-6804-1517
Xiongyu WuDepartment of Physics, Chemistry and Biology, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0001-6756-2276
Peter KonradssonDepartment of Physics, Chemistry and Biology, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0002-3416-0139
Svante VikingssonDivision of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0001-5977-3049
Robert KronstrandDivision of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0002-4222-9597
Henrik GréenDivision of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE 581 85 Linköping, Sweden.ORCID http://orcid.org/0000-0002-8015-5728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic cannabinoids (SC) target the human cannabinoid receptor 1 (hCB

Indexed as

Cannabinoid Receptor AgonistsCannabinoidsReceptor, Cannabinoid, CB1Computer SimulationDose-Response Relationship, DrugHumansIndolesMolecular Docking SimulationMolecular Dynamics SimulationNaphthalenesStructure-Activity Relationship1-pentyl-3-(1-naphthoyl)indoleCannabinoid Receptor AgonistsCannabinoidsIndolesNaphthalenesReceptor, Cannabinoid, CB1active metabolitesin silico docking and molecular dynamicspharmacodynamicsstructure-activity relationshipsynthetic cannabinoid receptor agonists

Identifiers

PMID41184621
PMCPMC12932713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.