ReviewActa pharmacologica Sinica2026
Targeting virus-interacting host ion channels as a novel antiviral strategy.
Review in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion channels are transmembrane protein complexes that control ion transport across the membranes and play a pivotal role for maintaining cellular homeostasis as well as in virus-host interactions. As obligate parasites, viruses hijack the host's ion channel network with spatiotemporal precision to drive their life cycle. In this review, we summarize the key function of ion channels in this dynamic interplay. We then delve into the ways by which different ion channel types facilitate discrete stages of viral infection, including entry, genome release, replication, assembly, and release. By examining dynamic changes in ion channel activity during infection, we reveal how viruses manipulate host ion channels to regulate their life cycle. Moreover, the clinical potential of targeting host ion channels as an innovative antiviral strategy is highlighted. The objective of this review is to comprehensively elucidate host ion channel-virus interactions, as well as the potential of existing ion channel modulators as antiviral drugs, laying the theoretical foundation for the development of novel antiviral therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.