Evidence map›Paper›PMID 41184615›Full record

ArticleJournal of integrative plant biology2026

Trichoderma genome and multiomics insight into promoting yield and reducing grain cadmium in barley and wheat.

Shuo Zhang, Cheng-Wei Qiu, Shou-Heng Shi, Jakkrit Sreesaeng, Zi-Feng Gao, Chulong Zhang, Weihua Mao, Mohamed Abdelalim Ali, Zhong-Hua Chen, Feibo Wu

Abstract read
In one paragraph

Article in Journal of integrative plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Dual Biocontrol and Plant Growth-Promoting Effects ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuo ZhangDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0001-6872-430X
Cheng-Wei QiuDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-3702-0975
Shou-Heng ShiDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-6272-9556
Jakkrit SreesaengDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-5899-8609
Zi-Feng GaoDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0008-2811-6554
Chulong ZhangMinistry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-5180-0348
Weihua MaoBio-Macromolecules Analysis Lab, Analysis Center of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0003-2044-9462
Mohamed Abdelalim AliMicrobiology Department, Faculty of Agriculture, Cairo University, Giza, 2613, Egypt.ORCID https://orcid.org/0000-0003-0227-7153
Zhong-Hua ChenSchool of Agriculture, Food & Wine, The University of Adelaide, Adelaide, 5005, SA, Australia.ORCID https://orcid.org/0000-0002-7531-320X
Feibo WuDepartment of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-8797-3398

Funding

National Natural Science Foundation of China 3211101286Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding, China
6 · The paper itself

Abstract

Soil cadmium (Cd) contamination poses significant risks to human health and environmental sustainability. Despite advances in bioremediation, effective bioagents with clear mechanistic insights for Cd detoxification are lacking. We first deciphered the whole-genome sequence of a novel Cd-tolerant Trichoderma nigricans T32781 and its in vivo heavy metal tolerance. In five independent pot and field trials, we revealed the T32781-induced alleviation mechanisms of plant-microbe-soil interactions in wheat and barley in response to Cd toxicity using a combination of agronomic, physiological, microbiome and metabolome approaches. We discovered that T32781 inoculation in soil significantly increased grain yield and decreased grain Cd concentration in barley and wheat exposed to different soil Cd levels. T32781 predominantly colonized soils, mitigating Cd toxicity by reducing soil Cd availability and promoting beneficial soil microbial communities and metabolites. These beneficial effects were further validated in the field, where the exogenous application of key metabolites induced by T32781 inoculation in soils and plants significantly increased grain yield and reduced grain Cd concentration in barley. This work highlights the potential of T32781 to enhance plant‒microbe-soil interactions and support sustainable and safe crop production in Cd-contaminated soils, addressing the increasing global demand for cereal production for food and feed.

Indexed as

CadmiumEdible GrainGenome, FungalHordeumTrichodermaTriticumMultiomicsSoil MicrobiologySoil PollutantsCadmiumSoil PollutantsCd immobilizationco‐occurrence networksoil metabolomesoil microbiomeTrichoderma nigricanswhole‐genome sequencing

Identifiers

PMID41184615
PMCPMC12782896

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.