ArticleNature methods2025
Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization.
Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
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26 authors.
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Abstract
Mapping of axon trajectories is crucial for understanding brain organization. Using whole-brain high-throughput fluorescence imaging, we developed a cytoarchitecture-based link estimation (CABLE) method for accurate fiber tract mapping at cellular resolution. This method infers the fiber direction from the inherent anisotropy of the nucleus or soma shape and spatial arrangement of adjacent cells. The inferred fiber tracts were validated by tracing virally labeled individual axons in the monkey brain. This CABLE method could disentangle complex intersecting or bending fibers that were uncertain in diffusion magnetic resonance imaging tractography, allowing accurate brain-wide fiber tract reconstruction in marmoset and macaque brains. Finally, we applied CABLE for rapid mapping of axon fiber abnormalities in diseased neonatal human brain tissues, establishing a path for high-resolution brain mapping of fiber tracts in the human brain.
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