ArticleNature genetics2025
Integrated metabolomic and transcriptomic analyses identify MYB genes regulating key metabolites and agronomic traits in upland cotton Gossypium hirsutum.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Genome-wide integrative dissection of genetic basis of fiber color and whiteness regulation in upland cotton (Gossypium hirsutum).BMC biology · 2026Article
- Natural variation inScience advances · 2026Article
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Authors and funding
27 authors.
Funding
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Abstract
Understanding early embryonic development is fundamental for unraveling plant cell differentiation and organogenesis. Here we integrate multiomics data from 403 upland cotton ovules to identify 2,960 metabolic quantitative trait loci and 24,485 expression quantitative trait loci. A key locus, ME_A07, influencing 252 known metabolite levels and expression of 4,293 genes, with the MYB gene GhTT2_A07 identified as central regulator, potentially regulated by a 520 kb inversion. GhTT2_A07 orchestrated both primary and secondary metabolite biosynthesis, influencing agronomic traits. Another locus, ME_A06, driven by the MYB gene Proanthocyanidin Regulator (GhPAR), modulates proanthocyanin content and suggests an ecological adaptation. GhTT2_A07 and GhPAR exhibit both shared and distinct expression profiles, contributing variably to fiber quality and yield. These findings highlight the critical role of MYB genes in the early development of cotton ovules and fibers, offering comprehensive multiomics resources that advance cotton research and molecular breeding.
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