ArticleInternational journal of legal medicine2026
Sequence homology between sex chromosomes leads to apparent heterozygosity at the DYS572 locus in massively parallel sequencing.
Article in International journal of legal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
In forensic genetics, Y-chromosomal short tandem repeats (Y-STRs) are widely used in male lineage tracing, kinship analysis, and mixture interpretation. Conventional genotyping of Y-STRs relies on length-based detection via capillary electrophoresis (CE). However, massively parallel sequencing (MPS) enables simultaneous determination of both length and sequence genotypes, thereby increasing the information obtained per assay. While developing and validating an MPS panel, we made an unexpected observation: the DYS572 locus exhibited heterozygous genotypes in both male and female samples. This could misidentify a single-source sample as a mixed sample. Reference sequence alignment revealed that the DYS572 region on the Y chromosome (GRCh38, chrY: 3,811,419-3,811,858) shares 98.41% sequence identity (432/439 bp) with a homologous region on the X chromosome (GRCh38, chrX: 90,242,118-90242557). The corresponding X-chromosomal region harbors seven single nucleotide variants (SNVs) distinguishing it from the Y sequence: four upstream of the repeat region at positions - 183 (rs1031074259), - 62 (rs34553462), - 56 (rs3959844), and - 47 (rs36022122), and three downstream at positions + 6 (rs35114058), + 96 (rs2752369), and + 194 (rs2752370). In practical applications, if primer design or bioinformatic filtering is suboptimal, amplification products of DYS572 may originate from the X chromosome. This study provides a thorough characterization of the DYS572 locus on the sex chromosomes, along with the genotyping patterns observed in males and females. This information will be valuable for future forensic applications.
Indexed as
Identifiers
41184531What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.