SynthesisScientific reports2025
Cognitive rehabilitation in anxiety disorders: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies.Molecular psychiatry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In this study, we sought to conduct a systematic review and meta-analysis of research that utilized cognitive rehabilitation to enhance cognitive functions and alleviate symptoms in adult patients with anxiety disorders. We selected controlled randomized clinical trials that used cognitive training and remediation interventions and published before June 2024 using search databases including PubMed, ScienceDirect, Scopus, Cochrane, and Proquest. For the meta-analysis, standard differences in means with the random effect model and with a 95% confidence interval of change in outcome measures from baseline to post-intervention between the cognitive rehabilitation and the control groups were calculated. The database search identified 1825 studies of interest, ultimately including eight studies with 242 participants in the cognitive rehabilitation group and 223 participants in the control group. The meta-analysis of the data extracted from these studies shows a small and significant effect on the symptom severity (d = 0.25 (95% CI, 0.02 to 0.47) p-value = 0.02, I2 = 30.12%), and a large and significant effect on the working memory (d = 0.84 (95% CI, 0.07 to 1.13) p-value = 0.02, I2 = 0.00%) of patients with anxiety disorders. However, there was no significant difference between the intervention and control groups regarding attention (d = 0.07 (95% CI, -0.25 to 0.4) p-value = 0.65, I2 = 0.00%). This systematic review and meta-analysis demonstrate that cognitive rehabilitation is an effective intervention for reducing symptom severity and improving working memory in patients with anxiety disorders. Given the significance of achieving complete remission from these disorders and addressing the neuropsychological deficits associated with anxiety, cognitive rehabilitation should be regarded as an essential component of treatment for anxious patients. Further research focusing on different anxiety diagnoses, cognitive deficits, and targeted interventions is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.