Evidence map›Paper›PMID 41184504›Full record

ArticleScientific reports2025

Deep‑learning based osteoporosis classification in knee X‑rays using transfer‑learning approach.

Muhammad Bilal Qureshi, Muhammad Sani, Ali Raza, Muhammad Shuaib Qureshi, Wajdi Alghamdi, Shahid Akbar, Rabiah Abdul Kadir, Mahidur R Sarker

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammad Bilal QureshiDepartment of Computer Science & IT, University of Lakki Marwat, Lakki Marwat, 28420, KPK, Pakistan.
Muhammad SaniDepartment of Computer Science & IT, University of Lakki Marwat, Lakki Marwat, 28420, KPK, Pakistan.
Ali RazaDepartment of Computer Science, Bahria University, Islamabad, 44220, Pakistan.
Muhammad Shuaib QureshiSchool of Computing Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, KPK, Pakistan. shuaib.qureshi@paf-iast.edu.pk.
Wajdi AlghamdiDepartment of Information Technology, Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Shahid AkbarDepartment of Computer Science, Abdul Wali Khan University Mardan, Mardan, 23200, KP, Pakistan. shahid.akbar@awkum.edu.pk.
Rabiah Abdul KadirInstitute of Visual Informatics, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia. rabiahivi@ukm.edu.my.
Mahidur R SarkerInstitute of Visual Informatics, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.

Funding

university research grant PP-IVI-2025
6 · The paper itself

Abstract

Bone deterioration from osteoporosis creates fractures that primarily affect females who have reached menopause and older adults. Early detection of osteoporosis requires affordable methods because current diagnostic systems are both expensive and challenging to use. The current application of deep learning models for bone radiography analysis faces three major limitations: shallow architecture, insufficient dataset adaptation, and inadequate feature extraction methods. Talk-based machine learning techniques rely heavily on human-generated feature construction; however, they fail to recognize the delicate image patterns that are present in medical contexts. VGG-16 provides strong power, but businesses must invest in advanced and expensive hardware platforms while maintaining challenges with data quantity. The detection of osteoporosis in knee X-rays through deep learning and the ResNet-50 model using transfer learning remains our primary proposal for solving existing issues. An overview of 372 X-ray images with verified medical information was constructed for T-score ratings determined using a quantitative ultrasound system. Following fine-tuning of our model based on ResNet-50, we achieved 90% accuracy, which exceeded all alternative models tested, including VGG-16 with 88% accuracy using fine-tuning, 80% without fine-tuning, a 3-layer CNN at 66%, ResNet-18 at 79%, and non-fine-tuned ResNet-50 at 83%. The clinical value of the ResNet-50 model stems from its high accuracy, strong sensitivity, and specificity rates. The detection reliability of osteoporosis by the deep transfer learning CNN ResNet-50 has been proven through these findings, which provide healthcare practitioners with an effective diagnostic tool for early detection and prevention of fractures. Our research indicates that deep learning using transfer learning strategies produces a crucial enhancement in medical imaging systems, leading to better patient results.

Indexed as

Deep LearningKneeOsteoporosisAgedFemaleHumansMaleMiddle AgedNeural Networks, ComputerRadiographyX-RaysCNNDeep learningOsteoporosisResNet-50Transfer learning

Identifiers

PMID41184504
PMCPMC12583545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.