Evidence map›Paper›PMID 41184436›Full record

Articlenpj antimicrobials and resistance2025

Identification of multidrug-resistant monophasic Salmonella Typhimurium ST34 and other NTS from animal-environmental origins in South Africa.

Samuel T Ogundare, Gaetan Thilliez, Matt Bawn, John-Paul Makumbi, Thabo Hamiwe, Folorunso O Fasina, Anthony M Smith, Gerbrand A van der Zel, Marleen M Kock, Peter F Geertsma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Genomic epidemiology ofOne health (Amsterdam, Netherlands) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel T OgundareDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. stogundare@gmail.com.
Gaetan ThilliezSchool of Biotechnology, Dublin City University, Dublin, Ireland.
Matt BawnUniversity of Newcastle, Newcastle upon Tyne, UK.
John-Paul MakumbiDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Thabo HamiweDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Folorunso O FasinaFood and Agriculture Organisation of the United Nations, FAO Headquarters, Rome, Italy.
Anthony M SmithDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Gerbrand A van der ZelGauteng Department of Agriculture, Rural Development and Environment, Pretoria, South Africa.
Marleen M KockDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Peter F GeertsmaGauteng Department of Agriculture, Rural Development and Environment, Pretoria, South Africa.
Marthie M EhlersDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-typhoidal Salmonella (NTS) causes approximately 155 000 deaths annually and poses significant risks to both human and animal health. Antimicrobial resistance (AMR) in NTS is a growing global public health threat. Using a One Health approach, this study investigated NTS in swine, poultry, and wastewater in Gauteng Province, South Africa. From May 2019 to August 2020, 507 samples were collected, including animal faeces (n = 388), hand swabs (n = 104), abattoir and farm run-off (n = 10), and hospital (n = 1) and municipal wastewater (n = 4). Whole genome sequencing of recovered isolates revealed a 2.37% (12/507) NTS prevalence, identifying four serovars: Salmonella Enteritidis sequence type (ST) 11 (n = 3), S. Infantis ST32 (n = 4), S. Irumu ST2026 (n = 2), and multidrug-resistant S. Typhimurium monophasic variant 1,4,[5],12:i:- ST34 (n = 3). The ST34 strains, detected in swine, exhibited ASSuT (ampicillin, streptomycin, sulfamethoxazole, tetracycline) resistance pattern and marked the first detection of ST34 from an animal source in Africa. The strains harboured a novel sopE-phage (AmTI) and SGI-4. Phylogenetic analysis linked these strains to human cases in South Africa and the UK, which could indicate transmission of MDR S. Typhimurium between animals and humans, underscoring the importance of enhanced AMR surveillance using a One Health approach.

Identifiers

PMID41184436
PMCPMC12583814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.