Evidence map›Paper›PMID 41184426›Full record

ArticleScientific reports2025

Decreased expression of BCL2 protein on the diagnostic bone marrow T cells in adult acute myeloid leukemia.

Zong-Yan Shi, Kai Sun, Ya-Zhe Wang, Dai-Hong Xie, Zhao-Yu Li, Qian Jiang, Hao Jiang, Ya-Zhen Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zong-Yan Shi *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Kai Sun *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Ya-Zhe WangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Dai-Hong XiePeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Zhao-Yu LiPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Qian JiangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Hao JiangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Ya-Zhen QinPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China. qin2000@aliyun.com.

Funding

National Natural Science Foundation of China 82070153
6 · The paper itself

Abstract

B-cell lymphoma-2 (BCL2) is an anti-apoptotic molecule. Previous studies on its function focused on leukemic cells in acute myeloid leukemia (AML), whereas its effect in lymphocytes is unclear. We performed multi-parameter flow cytometry to test BCL2, immune checkpoint and cytotoxic molecules on T and NK cells in bone marrow samples of 80 newly diagnosed adult AML patients and 7 healthy donors (HDs). BCL2 expression was evaluated on T-cell differentiation subsets in a subset of 28 AML patients and 6 additional HDs. AML patients had lower BCL2

Indexed as

Bone Marrow CellsLeukemia, Myeloid, AcuteProto-Oncogene Proteins c-bcl-2T-LymphocytesAdolescentAdultAgedAged, 80 and overFemaleHumansKiller Cells, NaturalMaleMiddle AgedYoung AdultBCL2 protein, humanProto-Oncogene Proteins c-bcl-2Acute myeloid leukemiaBCL2NK cellsPrognosisT cells

Identifiers

PMID41184426
PMCPMC12583805

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.