ArticleScientific reports2025
Mediation of blood lipid levels on the relationship between BMI/WHR and liver function in normal, overweight, and obese individuals.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sanhua Tea Alleviates Obesity Symptoms by Improving Blood Lipid Levels, Gut Microbiota, and Liver Metabolome in Mice.Foods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the impact of Body Mass Index (BMI) and Waist-to-Hip Ratio (WHR) on Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels, as well as the mediating role of lipid parameters: total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Understanding these associations is crucial for exploring the interplay between obesity, fatty liver disease, liver function impairment, and dyslipidemia. Conducted in Nantong City, Jiangsu Province, from July to September 2024, this research used a convenience sampling method involving 1,816 participants. Generalized Linear Models (GLM) and Restricted Cubic Splines (RCS) analyzed BMI/WHR's relationship with ALT/AST, while causal mediation analysis assessed lipid parameters' mediating effects. The findings indicated a positive correlation between both BMI and WHR with AST and ALT levels. The lipid indicators significantly mediated the relationship between BMI/WHR and AST/ALT, suggesting that obesity correlates with elevated liver enzyme levels and that blood lipid abnormalities may play an important intermediary role. This study enhances the understanding of interactions among obesity, fatty liver disease, liver function impairment, and dyslipidemia. It underscores the importance of addressing lipid abnormalities in managing obesity-related liver disease and calls for future research to explore underlying mechanisms and develop targeted interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.