ArticleScientific reports2025
Oral niacin mitigates heat-induced reproductive impairments in male mice.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Lactational exposure to polystyrene nanoplastics induces oxidative stress, testicular histological alterations, and impaired sperm quality in rat offspring.Histochemistry and cell biology · 2026Article
- Taurine Attenuates Repeated Heat Stress-Induced Male Reproductive Dysfunction in Mice: Associations with HPG Axis Homeostasis and Hypothalamic Microglial Changes.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Dietary Arginine Supplementation Mitigates Heat Stress-Induced Testicular Dysfunction Through Arginine-Related Metabolic Remodeling and Autophagy-Associated Stress Adaptation in a Rongchang Boar Model.Animals : an open access journal from MDPI · 2026Article
- Effect of Niacin Supplementation During In Vitro Maturation on Fertilization Rate and Mitochondrial Competence of Vitrified and Nonvitrified Bovine Oocytes.Veterinary medicine international · 2026Article
- Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Heat stress is a major environmental factor that impairs male fertility by disrupting hormonal regulation, increasing oxidative stress, and inducing germ cell apoptosis. Niacin (vitamin B3) has antioxidant and thermoregulatory properties that may counteract these effects. This study investigated whether oral niacin could protect against chronic heat stress-induced reproductive damage in adult BALB/c male mice. Mice were randomly assigned to Control, Heat Control, and two heat-stressed groups receiving niacin at 100 or 200 mg/kg/day for 30 days, with heat stress applied daily at 36 ± 2 °C for 4 h. Heat stress reduced body weight gain, testis and accessory gland weights, sperm count and motility, acrosome and DNA integrity, testosterone and thyroid hormones, and increased lipid peroxidation and pro-apoptotic gene expression. Niacin supplementation dose-dependently mitigated these effects: total sperm count increased from 9.8 × 10
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