Evidence map›Paper›PMID 41184380›Full record

ArticleScientific reports2025

PARP1-TRPM2-PKC cascade distinctly regulates reactive astrogliosis and clasmatodendrosis through NF-κB and AKT pathways in the hippocampus of chronic epilepsy rats.

Ji-Eun Kim, Su Hyeon Wang, Tae-Cheon Kang

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ji-Eun KimDepartment of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea. jieunkim@hallym.ac.kr.
Su Hyeon WangDepartment of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Tae-Cheon KangDepartment of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.

Funding

Hallym University HRFN-202410-002
6 · The paper itself

Abstract

The epileptic hippocampi of rodent models show reactive astrogliosis and autophagic astroglial death (clasmatodendrosis) in the CA1 region, which contributes to spontaneous seizures. Oxidative stress upregulates transient receptor potential melastatin 2 (TRPM2, a non-selective Ca

Indexed as

EpilepsyGliosisHippocampusNF-kappa BPoly (ADP-Ribose) Polymerase-1Proto-Oncogene Proteins c-aktTRPM Cation ChannelsAnimalsAstrocytesChronic DiseaseDisease Models, AnimalMaleRatsRats, Sprague-DawleySignal TransductionNF-kappa BParp1 protein, ratPoly (ADP-Ribose) Polymerase-1Proto-Oncogene Proteins c-aktTrpm2 protein, ratTRPM Cation ChannelsAstrocyteAutophagyDegenerationEpilepsyMicrogliap65PKCROS

Identifiers

PMID41184380
PMCPMC12583660

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.