Trial reportScientific reports2025
Acute high-intensity interval training, but not reduced-exertion high-intensity interval training increase brain-derived neurotrophic factor in a block randomized controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Exercise has been linked to various physical and mental health benefits with neuroplasticity being one of the potential pathways. Brain-derived neurotrophic factor (BDNF) has emerged as one of the most researched factors relating to exercise induced neuroplasticity. As exercise intensity and work to rest ratio differ between various exercise protocols, comparison of high-intensity interval training (HIIT) and reduced exertion high-intensity interval training (REHIT) could indicate a more optimal protocol for neuroplasticity promotion. In this study, 60 low to moderately active young adults took part in a block-randomized clinical trial comparing how acute 15-minute-long HIIT and REHIT affect BDNF and lactate levels, while the control group watched a video. Lactate was measured before and immediately after each intervention in capillary blood, while BDNF was measured in saliva, in the same timeframe. Mixed ANOVA and its nonparametric analogue were used to analyse time, group and time × group interaction effects. Lactate showed a group × time interaction effect, where concentration after exercise reached high concentration in HIIT as well as REHIT, around 9 and 13 mmol/l, respectively, with no change in the control group. BDNF analysis did not show time × group interactions. Median BDNF levels increased significantly by about 25% following HIIT, but no such change was observed in the other groups. Changes in lactate were not related to changes in BDNF in any of the groups. Future studies should test the effectiveness of HIIT in different populations, while exercise induced BDNF changes, as measured in saliva, should be compared to measurements in blood. In sum, the results suggest that an acute 15-minute HIIT can significantly raise BDNF levels in young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.