ArticleNature communications2025
Antibiotic resistance selection and deselection in municipal wastewater from 47 countries.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cobalt Single-Atom Catalysts for Ultrafast Sulfamethoxazole Degradation: Unveiling the Chloride-Ion-Enhanced Formation of Co(IV)=O.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative Molecular Characterization of Resistance and Virulence inMicroorganisms · 2026Article
- Alarming Antimicrobial Prescribing Patterns at a Tertiary Hospital in Nigeria: A Point Prevalence Survey using the Global-PPS Protocol.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Wastewaters are plausible arenas for antibiotic resistance evolution and transmission, yet selection for resistance by municipal wastewater has rarely been empirically demonstrated. Here, we experimentally investigate the potential of untreated municipal wastewater from 47 countries to select for antibiotic resistance and explore possible drivers. Using a functional selection assay with 340 mixed Escherichia coli strains, we find that sterile-filtered samples from 14 countries select significantly for resistance to at least one antibiotic class compared to baseline, while the majority select significantly against resistance. Similar results were generated using natural wastewater communities. Additionally, we report a comprehensive characterization of antibiotics and antibacterial biocides in the wastewaters. None of the 22 analyzed antibiotics could be assigned as key drivers for selection in E. coli, whereas e.g. folate pathway antagonists and macrolides often exceed predicted non-selective concentrations for other bacteria by >10-fold. Despite detecting 13 (out of 20 analyzed) organic antibacterial biocides, their potential for co-selection remains unclear. Measured chemical constituents correlate only weakly with observed selection, suggesting complex mixture effects and/or selection by unmeasured compounds. The clear deselection of resistance by most samples indicates that many resistant strains have impaired fitness in wastewaters with limited antibiotic selection pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.