Evidence map›Paper›PMID 41184148›Full record

Trial reportInvestigative and clinical urology2025

SHPro

Ji Hun Lee, Dahye Yoon, Geum Duck Park, Kyung Seok Kim, Soo Ro Kim, Woo Cheol Shin, Seung Hwan Lee, Dae Young Lee

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Investigative and clinical urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ji Hun LeeDepartment of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID 0009-0003-4047-3355
Dahye YoonDepartment of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Korea.ORCID 0000-0002-0286-8896
Geum Duck ParkSuheung Technology Research Institute, Gwacheon, Korea.ORCID 0009-0001-4632-3345
Kyung Seok KimSuheung Technology Research Institute, Gwacheon, Korea.ORCID 0000-0003-3791-4554
Soo Ro KimSuheung Technology Research Institute, Gwacheon, Korea.ORCID 0009-0007-4317-5272
Woo Cheol ShinBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Korea.ORCID 0009-0008-7429-1222
Seung Hwan LeeDepartment of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. leeseh@yuhs.ac.ORCID 0000-0001-7358-8544
Dae Young LeeBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Korea. dylee80@knu.ac.kr.ORCID 0000-0003-4302-3096

Funding

RDA RS-2021-RD009564
6 · The paper itself

Abstract

purposepreclinical trial confirmed that MATERIALS AND

methodsSubjects were divided into the treatment and control groups. They underwent four visits, and medication was initiated from the 2nd visit onwards, with a total of 12 weeks of intake. The endpoints were the International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF), prostate-specific antigen level, testosterone, dihydrotestosterone, maximal urinary flow rate, residual urine volume, and subjective evaluation improvement. Safety tests included clinical pathology tests and checking for adverse reactions.

resultsA total of 39 patients from the treatment group and 45 from the control group were included in the efficacy analysis. After 12 weeks, a significant improvement was seen in IPSS total score (p=0.0219) and incomplete emptying score (p=0.0007). Furthermore, there were statistically significant improvements in the IIEF total score, erectile function, sexual desire, intercourse satisfaction, and overall satisfaction in the treatment group. The subjective improvement evaluation also showed a significant improvement (p=0.0143). Ten cases of mild adverse events were reported, including gastrointestinal problems, skeletal pain, dermatitis, and others. However, no severe adverse reactions were observed, and it was unlikely that these were related to the test product.

conclusionsAfter taking the trial product (SHPro

Indexed as

AngelicaAstragalus propinquusDrugs, Chinese HerbalLower Urinary Tract SymptomsPhytotherapyPlant ExtractsProstatic HyperplasiaAgedDouble-Blind MethodHumansMaleMiddle AgedTreatment OutcomeDrugs, Chinese HerbalPlant ExtractsClinical trialDihydrotestosteronePharmacologic effectsSafetySHPro

Identifiers

PMID41184148
PMCPMC12599417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.